It’s the first test of a new era for the Springboks, with coach Peter de Villiers in charge for the first time.
Will the World Champions overcome numerous personnel changes both on and off the field to maintain their unbeaten home record against the Welsh?
Or will the 6 Nations champs under experienced coach Warren Gatland take advantage of the unsettled Springboks and record an upset victory?
Kick-off in Bloemfontein at 15:00 SA time.
Ref: Dave Pearson (England)
TJs: Lyndon Bray (New Zealand), Stuart Terheege (England)
TMO: Graham Hughes (England)
Starting XV: 15 Conrad Jantjes, 14 Tonderai Chavhanga, 13 Adrian Jacobs, 12 Jean de Villiers, 11 Bryan Habana, 10 Butch James, 9 Bolla Conradie, 8 Pierre Spies, 7 Juan Smith, 6 Luke Watson, 5 Andries Bekker, 4 Bakkies Botha, 3 Brian Mujati, 2 John Smit (captain), 1 Gürthro Steenkamp
Replacements: 16 Bismarck du Plessis, 17 CJ van der Linde, 18 Victor Matfield, 19 Danie Rossouw, 20 Ruan Pienaar, 21 Peter Grant, 22 Percy Montgomery
Starting XV:15 Jamie Roberts, 14 Mark Jones, 13 Tom Shanklin, 12 Sonny Parker, 11 Shane Williams, 10 Stephen Jones, 9 Gareth Cooper, 8 Ryan Jones (captain), 7 Dafydd Jones, 6 Jonathan Thomas, 5 Alun-Wyn Jones, 4 Ian Gough, 3 Gethin Jenkins, 2 Matthew Rees, 1 Adam Jones
Replacements: 16 Richard Hibbard, 17 Duncan Jones, 18 Ian Evans, 19 Gareth Delve, 20 Warren Fury, 21 James Hook, 22 Morgan Stoddard