The Boks beat the Welsh everywhere but in the scrums last week.
Will the foreigners hit back and score an unlikely victory at Fortress Loftus?
Or will the much stronger pack named by Peter de Villiers prove the final nail in the Welsh coffin?
Kick-off at Boerstadion is at 15h00 SA time.
South Africa: 15 Conrad Jantjes, 14 Tonderai Chavanga, 13 Adrian Jacobs, 12 Jean de Villiers, 11 Bryan Habana, 10 Butch James, 9 Ricky Januarie, 8 Pierre Spies, 7 Juan Smith, 6 Luke Watson, 5 Victor Matfield, 4 Bakkies Botha, 3 BJ Botha, 2 John Smit (c), 1 Tendai Mtawarira.
Replacements: 16 Bismarck du Plessis, 17 Gurthrö Steenkamp, 18 Andries Bekker, 19 Ryan Kankowski, 20 Bolla Conradie, 21 Francois Steyn, 22 Percy Montgomery.
Wales: 15 James Hook, 14 Mark Jones, 13 Tom Shanklin, 12 Jamie Roberts, 11 Shane Williams, 10 Stephen Jones, 9 Gareth Cooper, 8 Gareth Delve, 7 Jonathan Thomas, 6 Ryan Jones (c), 5 Alun Wyn Jones, 4 Ian Gough, 3 Rhys Thomas, 2 Richard Hibbard, 1 Gethin Jenkins.
Replacements: 16 T Rhys Thomas, 17 Duncan Jones, 18 Ian Evans, 19 Dafydd Jones, 20 Warren Fury, 21 Andrew Bishop, 22 Tom James.
Date: Saturday 14 June, 2008
Kick-off: 15:00 (13:00 GMT)
Venue: Loftus Versfeld, Pretoria
Weather: Clear skies and sunshine all day, highs of 20°C with a slight north-west wind
Referee: Lyndon Bray (New Zealand)
Touch judges: Dave Pearson (England), Stuart Terheege (England)
Television match official: Geoff Warren (England)
Assessor: Patrick Robin (France)