The clash across the Jukskei is the first of the Saturday evening matches in SA this week.
The Bulls are one of three undefeated teams left in this competition and will hope to keep it that way.
The Lions had a great start against the Cheetahs before going down to the Sharks last weekend.
Will Bulls manage to go 1 point clear at the top of the log courtesy of three back to back bonus point wins?
Or will the Lions show that the win against the Cheetahs was no flash in the pan?
Venue: Coca Cola Park, Johannesburg
Kick-off: 17.00 local time
Referee: Phillip Bosch (South Africa)
ARs: Jonathan Kaplan (South Africa), Sindile Mayende (South Africa)
TMO: Johann Meuwesen (South Africa)
15 Louis Ludik, 14 Ashwin Willemse, 13 Jaque Fourie, 12 Doppies le Grange, 11 Henno Mentz, 10 Earl Rose, 9 Jano Vermaak, 8 Willem Alberts, 7 Ernst Joubert, 6 Cobus Grobbelaar (captain), 5 Gerhard Mostert, 4 Anton van Zyl, 3 Lawrence Sephaka/Gert Muller, 2 Willie Wepener, 1 Heinke van der Merwe/Lawrence Sephaka.
16 Hans van Dyk, 17 Gert Muller/JC Janse van Rensburg, 18 Franco van der Merwe, 19 Todd Clever, 20 Chris Jonck, 21 Andre Pretorius/Divan Kotze, 22 Jannie Boshoff.
15 Zane Kirchner, 14 Akona Ndungane, 13 Jaco Pretorius, 12 Wynand Olivier, 11 Bryan Habana, 10 Morné Steyn, 9 Fourie du Preez (captain), 8 Pierre Spies, 7 Dewald Potgieter, 6 Deon Stegmann, 5 Danie Rossouw, 4 Bakkies Botha, 3 Werner Kruger, 2 Chiliboy Ralepelle, 1 Gurthrö Steenkamp.
16 Derick Kuün, 17 Rayno Gerber, 18 Wilhelm Steenkamp, 19 Pedrie Wannenburg, 20 Heini Adams, 21 Burton Francis, 22 JP Nel.