The Boks now have their backs against the wall, having lost 3 matches in a row on their ill-fated end-of-year tour.
Will the ever-improving Italy, with their strong scrum and never-say-die Italy, be able to score their first-ever victory over the Boks?
Or will John and the boys overcome the wiley Nick Mallett and his azure brigade to finally get the tour back on track?
Kick-off in Udine is at 16h00 SA Time.
Italy: 15 Luke McLean, 14 Matteo Pratichetti, 13 Alberto Sgarbi, 12 Gonzalo Garcia, 11 Mirco Bergamasco, 10 Craig Gower, 9 Simon Piccone, 8 Sergio Parisse, 7 Alessandro Zanni, 6 Simone Favaro, 5 Quintin Geldenhuys, 4 Carlo Del Fava, 3 Martin Castrogiovanni, 2 Fabio Ongaro, 1 Salvatore Perugini
Replacements: 16 Leonardo Ghiraldini, 17 Ignacio Rouyet, 18 Antonio Pavanello, 19 Josh Sole, 20 Mauro Bergamasco, 21 Tito Tebaldi, 22 Gonzalo Canale
South Africa: 15 Zane Kirchner, 14 JP Pietersen, 13 Jaque Fourie, 12 Adi Jacobs, 11 Bryan Habana, 10 Morné Steyn, 9 Fourie du Preez, 8 Ryan Kankowski, 7 Danie Rossouw, 6 Heinrich Brüssow, 5 Andries Bekker, 4 Bakkies Botha, 3 John Smit (captain), 2 Adriaan Strauss, 1 Wian du Preez.
Replacements: 16 Tendai Mtawarira, 17 BJ Botha, 18 Victor Matfield, 19 Jean Deysel, 20 François Hougaard, 21 Ruan Pienaar, 22 Wynand Olivier.
Referee: Alain Rolland (Ireland)
Assistant referees: James Jones (Wales), Peter Allan (Scotland)
TMO: Hugh Watkins (Wales)