Danie Rossouw has been withdrawn from the side to face Italy in the second test taking place in East London.
Rossouw injured his hip during training this week but will be fit for the Tri Nations tour that starts next month.
He will be replaced by fellow Bulls teammate Flip VD Merwe.
The revised team is as follows:
15. Gio Aplon, 14. Jean de Villiers, 13. Jaque Fourie, 12. Juan de Jongh, 11. Bryan Habana, 10. Morné Steyn, 9. Ricky Januarie, 8. Pierre Spies, 7. Francois Louw, 6. Schalk Burger, 5. Andries Bekker, 4. Bakkies Botha, 3. Jannie du Plessis, 2. John Smit (captain), 1. Gurthrö Steenkamp
Substitutes: 16. Chiliboy Ralepelle, 17. BJ Botha, 18. Flip van der Merwe, 19. Dewald Potgieter, 20. Ruan Pienaar, 21. Butch James, 22. Wynand OliverTweet